Publications from Bin Tian Laboratory Lab Home


  • Hou L, Wang Y, Liu Y, Zhang N, Shamovsky I, Nudler E, Tian B, Dynlacht, BD. (2019) Paf1C regulates RNA polymerase II progression by modulating elongation rate. Proc Natl Acad Sci USA. In press.
  • Fischl H, Neve J, Wang Z, Patel R, Louey A, Tian B, Furger A. (2019) hnRNPC regulates cancer-specific alternative cleavage and polyadenylation profiles. Nucleic Acids Res. In press.
  • Fan J, Wang K, Du X, Wang J, Chen S, Wang Y, Shi M, Zhang L, Wu X, Zheng D, Wang C, Wang L, Tian B, Li G, Zhou Y, Cheng H. (2019) ALYREF links 3'-end processing to nuclear export of non-polyadenylated mRNAs. EMBO J. 38:e99910.
  • Wang R, Zheng D, Wei L, Ding Q, Tian B. (2019) Regulation of intronic polyadenylation by PCF11 impacts mRNA expression of long genes. Cell Rep. 26:2766-2778.e6.
  • Chen S*, Wang R*, Zheng D*, Zhang H*, Chang X, Wang K, Li W, Fan J, Tian B#, Cheng H#. (2019) The mRNA export receptor NXF1 coordinates transcriptional dynamics, alternative polyadenylation and mRNA export. Mol Cell. 74:118-131.
  • Michinari Nakamura M, Liu T, Husain S, Zhai P, Warren JS, Hsu CP, Matsuda T, Phiel CJ, Cox JE, Tian B, Li H, Sadoshima J. (2019) Glycogen Synthase Kinase-3a Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy. Cell Metabolism. 29:1119-1134.
  • Ikeda S, Mizushima W, Sciarretta S, Abdellatif M, Zhai P, Mukai R, Fefelova N, Oka SI, Nakamura M, Del Re DP, Farrance IK, Park JY, Tian B, Xie LH, Kumar M, Hsu CP, Sadayappan S, Shimokawa H, Lim DS, Sadoshima J. (2019). Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte De-Differentiation During Pressure Overload. Circ Res. 124:292-305.


  • Ogorodnikov A, Levin M, Tattikota S, Tokalov S, Hoque M, Scherzinger D, Marini F, Poetsch A, Binder H, Macher-Goeppinger S, Tian B, Schaefer M, Lackner K, Westermann F, Danckwardt S. (2018). PCF11 connects alternative polyadenylation to formation and spontaneous regression of neuroblastoma. Nat Commun. 9:5331.
  • Fomin V, Richard P, Hoque M, Li C, Gu Z, Fissore-O'Leary M, Tian B, Prives C, Manley JL. (2018). The C9ORF72 gene, implicated in ALS/FTD, encodes a protein that functions in control of endothelin and glutamate signaling. Mol Cell Biol. 38:e00155-18.
  • Larochelle M, Robert MA, Hebert JN, Liu XC, Matteau D, Rodrigue S, Tian B, Jacques PE, Bachand F. (2018). Cleavage-dependent transcription termination at coding and noncoding RNA genes in the absence of a Nrd1-Nab3-Sen1 termination pathway. Nat Commun. 9:4364.
  • Wang R, Zheng D, Yehia G, Tian B. (2018). A compendium of conserved cleavage and polyadenylation events in mammals. Genome Res. 10:1427-1441.
  • Guvenek A, Tian B. (2018). Analysis of alternative cleavage and polyadenylation in mature and differentiating neurons using RNA-seq data. Quant Biol. 6:253. [Cover Story]
  • Zheng D*, Wang R*, Ding Q, Wang T, Xie B, Wei L, Zhong Z, Tian B. (2018). Cellular stress alters 3'UTR landscape through alternative polyadenylation and isoform-specific degradation. Nat Commun. 9:2268
  • Wang R, Nambiar R, Zheng D, Tian B. (2018). PolyA_DB 3 catalogs cleavage and polyadenylation sites identified by deep sequencing in multiple genomes. Nucleic Acids Res. 46:D315-D319.


  • Fontes MM*, Guvenek A*, Kawaguchi R, Zheng D, Huang A, Ho VM, Chen PB, Liu X, O'Dell TJ, Coppola G, Tian B#, Martin KC#. (2017). Activity-Dependent Regulation of Alternative Cleavage and Polyadenylation During Hippocampal Long-Term Potentiation. Sci Rep. 7:17377.
  • Yurko N, Liu X, Yamazaki T, Hoque M, Tian B, Manley JL. (2017). MPK1/SLT2 Links Multiple Stress Responses with Gene Expression in Budding Yeast by Phosphorylating Tyr1 of the RNAP II CTD. Mol Cell. 68:913-925.
  • Liu X*, Freitas J*, Hoque M, Oliveira MS, Martins T, Henriques T, Tian B#, Moreira A#. (2017). RNA polymerase II dynamics has a tissue-specific impact in alternative cleavage and polyadenylation in Drosophila melanogaster. RNA. 23:1807-1816
  • Liu X, Hoque M, Larochelle M, Lemay JF, Yurko N, Manley JL, Bachand F, Tian B. (2017). Comparative Analysis of Alternative Polyadenylation in S. cerevisiae and S. pombe. Genome Res. 27:1685-1695.
  • Shi M, Zhang H, Wu X, He Z, Wang L, Yin S, Tian B, Li G, Cheng H. (2017). ALYREF mainly binds to the 5' and the 3' regions of the mRNA in vivo. Nucleic Acids Res. 45:9640-9653.
  • Li W*, Li W*, Laishram RS, Hoque M, Ji Z, Tian B#, Anderson RA#. (2017). Distinct regulation of alternative polyadenylation and gene expression by nuclear poly(A) polymerases. Nucleic Acids Res. 45:8930-8942.
  • Vest KE, Phillips BL, Banerjee A, Apponi LH, Dammer EB, Xu W, Zheng D, Yu J, Tian B, Pavlath GK, Corbett AH. (2017). Novel mouse models of oculopharyngeal muscular dystrophy (OPMD) reveal early onset mitochondrial defects and suggest loss of PABPN1 may contribute to pathology. Hum Mol Genet. 26:3235-3252.
  • Hoque M, Park JY, Chang Y, Luchessi AD, Cambiaghi TD, Shamanna R, Hanauske-Abel HM, Holland B, Pe'ery T, Tian B, Mathews MB. (2017). Regulation of gene expression by translation factor eIF5A: Hypusine-modified eIF5A enhances nonsense-mediated mRNA decay in human cells. Translation. 5:e1366294.
  • Ogami K, Richard P, Chen Y, Hoque M, Li W, Moresco JJ, Yates JR 3rd, Tian B, Manley JL. (2017). An Mtr4/ZFC3H1 complex facilitates turnover of unstable nuclear RNAs to prevent their cytoplasmic transport and global translational repression. Genes Dev. 31: 1257-1271.
  • Elbarbary RA, Miyoshi K, Myers JR, Du P, Ashton JM, Tian B, Maquat LE. (2017). Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition. Science. 356:859-862.
  • Hu W, Li S, Park JY, Boppana S, Ni T, Li M, Zhu J, Tian B, Xie Z, Xiang M. (2017). Dynamic landscape of alternative polyadenylation during retinal development. Cell Mol Life Sci. 74:1721-1739.
  • Zheng D, Tian B. (2017). Polyadenylation Site-Based Analysis of Transcript Expression by 3'READS. Methods Mol Biol. 1648:65-77.
  • Tian B#, Manley JL# (2017). Alternative polyadenylation of mRNA precursors. Nat Rev Mol Cell Biol. 18:18-30.
  • Hrdlickova R, Toloue M#, Tian B#. (2017). RNA-Seq methods for transcriptome analysis. WIRES RNA. doi: 10.1002/wrna.1364.


  • Blair LP, Liu Z, Lorenzo RD. Labitigan, Wu L, Zheng D, Xia Z, Pearson EL, Nazeer FI, Cao J, Lang SM, Rines RJ, Mackintosh SG, Moore CL, Li W, Tian B, Tackett AJ, Yan Q. KDM5 Lysine Demethylases Are Involved in Maintenance of 3'UTR Length. (2016). Sci Adv. 2:e1501662.
  • Miles WO, Lembo A, Volorio A, Brachtel E, Tian B, Sgroi D, Provero P, Dyson NJ. (2016). Alternative polyadenylation in triple-negative breast tumors allows NRAS and c-JUN to bypass PUMILIO post-transcriptional regulation. Cancer Res. 76:7231-41.
  • Tahmasebi S, Jafarnejad SM, Tam IS, Gonatopoulos-Pournatzis T, Matta-Camacho E, Tsukumo Y, Yanagiya A, Li W, Atlasi Y, Caron M, Braunschweig U, Pearl D, Khoutorsky A, Gkogkas CG, Nadon R, Bourque G, Yang XJ, Tian B, Stunnenberg HG, Yamanaka Y, Blencowe BJ, Giguere V, Sonenberg N. (2016). Control of embryonic stem cells self-renewal and differentiation via coordinated splicing and translation of YY2. PNAS. 113:12360-12367.
  • Zheng D, Liu X, Tian B. (2016). 3'READS+, a sensitive and accurate method for 3' end sequencing of polyadenylated RNA. RNA. 22:1631-9.
  • Matsuda T, Zhai P, Sciarretta S, Zhang Y, Jeong JI, Ikeda S, Park JY, Hsu CP, Tian B, Pan D, Sadoshima J, Del Re DP. (2016). NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in Heart. Circ Res. 119:596-606.
  • Lemay JF, Marguerat S, Larochelle M, Liu X, van Nues R, Hunyadkurti J, Hoque M, Tian B, Granneman S, Bahler J, Bachand F. (2016). The Nrd1-like protein Seb1 coordinates cotranscriptional 3' end processing and polyadenylation site selection. Genes Dev. 30:1558-72.
  • Yang Q, Lin J, Liu M, Li R, Tian B, Zhang X, Xu B, Liu M, Zhang X, Li Y, Shi H, Wu L. (2016). Highly sensitive sequencing reveals dynamic modifications and activities of small RNAs in mouse oocytes and early embryos. Sci Adv. 2:e1501482.
  • Devany E*, Park JY*, Murphy MR*, Zakusilo G, Baquero J, Zhang X, Hoque M, Tian B#, Kleiman FE#. (2016). Intronic cleavage and polyadenylation regulates gene expression during DNA damage response through U1 snRNA. Cell Discovery 2:16013.
  • Wu S, Marie Lutz B, Miao X, Liang L, Mo K, Chang YJ, Du P, Soteropoulos P, Tian B, Kaufman AG, Bekker A, Hu Y, Tao YX. (2016). Dorsal root ganglion transcriptome analysis following peripheral nerve injury in mice. Mol Pain. 12:1744806916629048.
  • Li W, Park JY, Zheng D, Hoque M, Yehia G, Tian B. (2016). Alternative cleavage and polyadenylation in spermatogenesis connects chromatin regulation with post-transcriptional control. BMC Biol. 14(1):6.
  • Yang Y*, Li W*, Hoque M, Hou L, Shen S, Tian B#, Dynlacht BD#. (2016). PAF Complex Plays Novel Subunit-specific Roles in Alternative Cleavage and Polyadenylation. PLoS Genet. 12(1):e1005794.
  • Neve J, Burger K, Li W, Hoque M, Patel R, Tian B, Gullerova M, Furger A. (2016). Subcellular RNA profiling links splicing and nuclear DICER1 to alternative cleavage and polyadenylation. Genome Res. 26:24-35.


  • Yang Y, Del Re DP, Nakano N, Sciarretta S, Zhai P, Park J, Sayed D, Shirakabe A, Matsushima S, Park Y, Tian B, Abdellatif M, Sadoshima J. (2015). miR-206 Mediates YAP-Induced Cardiac Hypertrophy and Survival. Circ Res. 117:891.
  • Dai W, Li W, Hoque M, Li Z, Tian B#, Makeyev EV#. (2015). A post-transcriptional mechanism pacing expression of neural genes with precursor cell differentiation status. Nat Commun. 6:7576.
  • Tzeng J, Byun J, Park JY, Yamamoto T, Schesing K, Tian B, Sadoshima J, Oka S. (2015). An Ideal PPAR Response Element Bound to and Activated by PPARalpha. PLoS One. 10:e0134996.
  • Pfister NT, Fomin V, Regunath K, Zhou JY, Zhou W, Silwal-Pandit L, Freed-Pastor WA, Laptenko O, Neo SP, Bargonetti J, Hoque M, Tian B, Gunaratne J, Engebraaten O, Manley JL, Borresen-Dale AL, Neilsen PM, Prives C. (2015). Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells. Genes Dev. 29:1298-315.
  • Li W, You B, Hoque M, Luo W, Park JY, Ji Z, Zheng D, Gunderson SI, Kalsotra A, Manley JL, Tian B. (2015). Systematic profiling of poly(A)+ transcripts modulated by core 3' end processing and splicing factors reveals regulatory rules of alternative cleavage and polyadenylation. PLoS Genet. 11(4):e1005166.
  • Jin Y, Geisberg JV, Moqtaderi Z, Ji Z, Hoque M, Tian B, Struhl K. (2015). Mapping 3' mRNA isoforms on a genomic scale. Curr Protoc Mol Biol. 110:4.23.1-4.23.17.


  • Di Giammartino DC, Li W, Yashinskie Jossie, Hoque M, Tian B, Manley, JL. (2014). RBBP6 is a human polyadenylation factor that regulates mRNAs with AU-rich 3'UTRs. Genes Dev. 28:2248-60.
  • Zheng D, Tian B. (2014). RNA-Binding Proteins in Regulation of Alternative Cleavage and Polyadenylation. Adv Exp Med Biol. 825:97-127.
  • Kurosaki T, Li W, Hoque M, Popp MWL, Ermolenko D, Tian B, Maquat LE. (2014). A post-translational regulatory switch on UPF1 controls targeted mRNA degradation. Genes Dev. 28:1900-1916.
  • Rosonina E, Yurko NM, Li W, Hoque M, Tian B, Manley JL. (2014). Threonine-4 of the yeast RNAP II CTD couples transcription with Htz1-mediated chromatin remodeling. Proc Natl Acad Sci USA. 111:11924-31.
  • Hsin JP, Li W, Hoque M, Tian B, Manley JL. (2014). RNAP II CTD tyrosine 1 performs diverse functions in vertebrate cells. Elife. 3:e02112.
  • Zheng D, Tian B. (2014). Sizing up the poly(A) tail: insights from deep sequencing. Trends Biochem Sci. 39:255-7.
  • Hoque M, Li W, Tian B. (2014). Accurate mapping of cleavage and polyadenylation sites by 3' region extraction and deep sequencing. Methods Mol Biol. 1125:119-29.


  • Prasad MK, Bhalla K, Pan Z, O`Connell JR, Weder AB; Chakravarti A, Tian B, Chang YC. (2013). A polymorphic 3'UTR element in ATP1B1 regulates alternative polyadenylation and is associated with blood pressure. PLoS ONE. 8:e76290.
  • Cheng Y, Tian B, Miura TM. (2013). Mathematical modeling of alternative polyadenylation in the human gene, CSTF3. SIAM J. Appl. Math. 73:1793-1810.
  • Luo W*, Ji Z*, Pan Z*, You B, Hoque M, Li W, Gunderson SI, Tian B. (2013). The Conserved Intronic Cleavage and Polyadenylation Site of CstF-77 Gene Imparts Control of 3' End Processing Activity through Feedback Autoregulation and by U1 snRNP. PLoS Genet. 9:e1003613.
  • Elbarbary RA, Li W, Tian B, Maquat LE. (2013). STAU1 binding 3' UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown. Genes Dev. 27:1495-1510.
  • Tian B#, Manley JL#. (2013). Alternative Cleavage and Polyadenylation: the long and short of it. Trends Biochem Sci. 38:312-20.
  • Devany E, Zhang X, Park JY, Tian B, Kleiman FE. (2013). Positive and negative feedback loops in the p53 and mRNA 3' processing pathways.(2013). Proc Natl Acad Sci USA. 110:3351-6.
  • Matsushima S, Kuroda J, Ago T, Zhai P, Park JY, Xie LH, Tian B, Sadoshima J. (2013). Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy. Circ Res. 112:651-63.
  • Hoque M*, Ji Z*, Zheng D, Luo W, Li W, You B, Park JY, Yehia G, Tian B. (2013). Analysis of alternative cleavage and polyadenylation by 3' region extraction and deep sequencing. Nat Methods. 10:133-9.


  • Larsson O, Tian B, Sonenberg N. (2012). Toward a Genome-Wide Landscape of Translational Control. Cold Spring Harb Perspect Biol. 5:a012302.
  • Bravo C, Kudej RK, Yuan C, Yoon S, Ge H, Park JY, Tian B, Stanley WC, Vatner SF, Vatner DE, Yan L. (2012). Metabolomic Analysis of Two Different Models of Delayed Preconditioning.J Mol Cell Cardiol. 55:19-26.
  • Li W*, Yeh HJ*, Shankarling GS, Ji Z, Tian B, Macdonald CC. (2012). The tCstF-64 Polyadenylation Protein Controls Genome Expression in Testis. PLoS ONE. 7:e48373.
  • Yan L, Park JY, Dillinger JG, De Lorenzo MS, Yuan C, Lai L, Wang C, Ho D, Tian B, Stanley WC, Auwerx J, Vatner DE, Vatner SF. (2012). Common Mechanisms for Calorie Restriction and AC5 Knockout Models of Longevity. Aging Cell. 11:1110-20.
  • Henriques T, Ji Z, Tan-Wong SM, Carmo AM, Tian B, Proudfoot NJ, Moreira A. (2012). Transcription termination between polo and snap, two closely spaced tandem genes of D. melanogaster. Transcription. 3:198-212.
  • Yin J, Liang Y, Park JY, Chen D, Xiao Y, Xiao Q, Liu Z, Jiang B, Fu Y, Huang Y, Liu Y, Yan J, Zhu M, Yang Z, Gao P, Tian B, Li D, Wang G. (2012). The Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation. Genes Dev. 26:2192-205.
  • Lee JE, Lee JY, Trembly J, Wilusz J, Tian B, Wilusz CJ. (2012). The PARN deadenylase targets a discrete set of mRNAs for decay and regulates cell motility in mouse myoblasts. PLoS Genetics. 8:e1002901.
  • Neff AT, Lee JY, Wilusz J, Tian B, Wilusz CJ. (2012). Global analysis reveals multiple pathways for unique regulation of mRNA decay in induced pluripotent stem cells. Genome Res. 22:1457-67.
  • Xie LH, Shanmugam M, Park JY, Zhao Z, Wen H, Tian B, Periasamy M, Babu GJ. (2012). Ablation of sarcolipin results in atrial remodeling. Am J Physiol Cell Physiol. 302:C1762-71.
  • Haenni S*, Ji Z*, Hoque M, Rust N, Sharpe H, Eberhard R, Browne C, Hengartner MO, Mellor J, Tian B#, Furger A#. (2012). Analysis of C. elegans intestinal gene expression and polyadenylation by fluorescence-activated nuclei sorting and 3'-end-seq. Nucleic Acids Res. 40:6304-18.
  • Oka SI, Zhai P, Alcendor R, Park JY, Tian B, Sadoshima J. (2012). Suppression of ERR targets by a PPARalpha/Sirt1 complex in the failing heart. Cell Cycle. 11:856-64.
  • Zhao X, Park J, Ho D, Gao S, Yan L, Ge H, Ilsmaa S, Lin L, Tian B, Vatner DE, Graham RM, Vatner SF. (2012). Cardiomyocyte Overexpression of the alpha1A-Adrenergic Receptor in the Rat Phenocopies Second But Not First Window Preconditioning. Am J Physiol Heart Circ Physiol. 302:H1614-24.
  • Huang Y, Li W, Yao X, Lin Q, Yin J, Heiner M, Tian B, Hui J, Wang G. (2012). Mediator Complex Regulates Alternative mRNA Processing via the Med23 Subunit. Mol Cell. 45:459-469.
  • Freed-Pastor WA, Mizuno H, Zhao X, Langerød A, Chicas A, Li W, Polotskaia A, Bissell MJ, Tian B, Lowe SW, Dale AB, Levine AJ, Bargonetti J, Prives C. (2012). Mutant p53 Disrupts Mammary Acinar Morphogenesis via the Sterol Biosynthesis Pathway. Cell. 148:244-58.
  • Li W, Laishram RS, Ji Z, Barlow CA, Tian B, Anderson RA. (2012). Star-PAP Control of BIK Expression and Apoptosis is Regulated by Nuclear PIPKI-alpha and PKC-delta Signaling. Mol Cell. 45:25-37.


  • Oka S, Alcendor R, Zhai P, Park JY, Shao D, Cho J, Yamamoto T, Tian B, Sadoshima J. (2011). PPARalpha-Sirt1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway. Cell Metab. 14:598-611.
  • Ji Z*, Luo W*, Li W, Hoque M, Pan Z, Zhao Y, Tian B. (2011). Transcriptional activity regulates alternative cleavage and polyadenylation. Mol Syst Biol. 7:534. Featured Article.
  • Tian B, Graber JH. (2011). Signals for Pre-mRNA Cleavage and Polyadenylation. WIRES RNA.
  • Park JY, Li W, Zheng D, Zhai P, Zhao Y, Matsuda T, Vatner SF, Sadoshima J, Tian B. (2011). Comparative analysis of mRNA isoform expression in cardiac hypertrophy and development reveals multiple post-transcriptional regulatory modules. PLoS ONE 6(7): e22391.
  • Qiu H, Lizano P, Laure L, Sui X, Rashed E, Park JY, Hong C, Gao S, Holle E, Morin D, Dhar SK, Wagner T, Berdeaux A, Tian B, Vatner SF, Depre C. (2011). H11 Kinase/Heat Shock Protein 22 Deletion Impairs Both Nuclear and Mitochondrial Functions of STAT3 and Accelerates the Transition Into Heart Failure on Cardiac Overload. Circulation. 124:406-15.
  • Usui S, Maejima Y, Pain J, Hong C, Cho J, Park JY, Zablocki D, Tian B, Glass DJ, Sadoshima J. (2011). Endogenous Muscle Atrophy F-Box Mediates Pressure Overload-Induced Cardiac Hypertrophy Through Regulation of Nuclear Factor-{kappa}B. Circ Res. 109:161-71.
  • Parrott AM, Tsai M, Batchu P, Ryan K, Ozer HL, Tian B, Mathews MB. (2011). The evolution and expression of the snaR family of small non-coding RNAs. Nucleic Acids Res. 39:1485-1500.
  • Zhao Q, Beck AJ, Vitale JM, Schneider JS, Gao S, Chang C, Elson G, Leibovich SJ, Park JY, Tian B, Nam HS, Fraidenraich D. (2011). Developmental ablation of Id1 and Id3 genes in the vasculature leads to postnatal cardiac phenotypes. Dev Biol. 349:53-64.


  • Depre C, Park JY, Shen YT, Zhao X, Qiu H, Yan L, Tian B, Vatner SF, Vatner DE. (2010). Molecular Mechanisms Mediating Preconditioning Following Chronic Ischemia Differ from those in Classical Second Window. Am J Physiol Heart Circ Physiol. 299:H752-62.
  • Lee JE*, Lee JY*, Wilusz J, Tian B, Wilusz CJ. (2010). Systematic Analysis of Cis-Elements in Unstable mRNAs Demonstrates that CUGBP1 Is a Key Regulator of mRNA Decay in Muscle Cells. PLoS One. 5:e11201.
  • Newnham CM, Hall-Pogar T, Liang S, Wu J, Tian B, Hu J, Lutz CS. (2010). Alternative polyadenylation of MeCP2: Influence of cis-acting elements and trans-acting factors. RNA Biol. 7:3.
  • Nunes NM, Li W, Tian B, Furger A. (2010). A functional human Poly(A) site requires only a potent DSE and an A-rich upstream sequence. EMBO J. 29:1523-36.



  • Matsuda T, Zhai P, Maejima Y, Hong C, Gao S, Tian B, Goto K, Takagi H, Tamamori-Adachi M, Kitajima S, Sadoshima J. (2008). Distinct roles of GSK-3{alpha} and GSK-3{beta} phosphorylation in the heart under pressure overload. Proc. Natl. Acad. Sci. U. S. A. 105:20900-5.
  • Shen Y-T, Depre C, Yan L, Park JY, Tian B, Jain K, Chen L, Zhang Y, Kudej RK, Zhao X, Sadoshima J, Vatner DE, Vatner SF. (2008). Repetitive Ischemia Induces a Novel Window of Ischemic Preconditioning. Circulation. 118:1961-9.
  • Lee JY, Ji Z, Tian B. (2008). Phylogenetic analysis of mRNA polyadenylation sites reveals a role of transposable elements in evolution of the 3' end of genes. Nucleic Acids Res. 36:5581-90.
  • Tian B. (2008). Alternative Polyadenylation in the Human Genome: Evolution. ENCYCLOPEDIA OF LIFE SCIENCES. DOI: 10.1002/9780470015902.a0020768
  • Qiu H, Dai H, Jain K, Shah R, Hong C, Pain J, Tian B, Vatner DE, Vatner SF, Depre C. (2008). Characterization of a novel cardiac isoform of the cell cycle-related kinase that is regulated during heart failure. J. Biol. Chem. 283:22157-65.
  • Khaladkar M, Liu J, Wen D, Wang JTL, Tian B. (2008). Mining Structural Elements in Human and Mouse Untranslated Regions of mRNAs using Structure-based Alignment. BMC Genomics 9:189.
  • Lee JY, Park JY, Tian B. (2008). Identification of mRNA polyadenylation sites in genomes using cDNA sequences, expressed sequence tags and Trace. Methods Mol. Biol. 419:23-37.


  • Dass B, Tardif S, Park JY, Tian B, Weitlauf HM, Hess RA, Carnes K, Griswold MD, Small CL, Macdonald CC. (2007) Loss of polyadenylation protein tCstF-64 causes spermatogenic defects and male infertility. Proc. Natl. Acad. Sci. U.S.A. 104:20374-9
  • Terskiy A, Wannemacher KM, Yadav PN, Tsai M, Tian B, Howells RD. (2007). Search of the human proteome for endomorphin-1 and endomorphin-2 precursor proteins. Life Sciences. 81:1593-601.
  • Young TM, Tsai M, Tian B, Mathews MB, Pe'ery T. (2007). Cellular mRNA Activates Transcription Elongation by Displacing 7SK RNA. PLoS ONE. 2(10):e1010.
  • Kirchner S, McDaniel NK, Sugiura SH, Soteropoulos P, Tian B, Fletcher JW, Ferraris RP. (2007). Salmonid microarrays identify intestinal genes that reliably monitor P-deficiency in rainbow trout aquaculture. Anim. Genet. 38:319-31.
  • Khaladkar M, Bellofatto V, Wang JTL, Tian B, Shapiro BA. (2007). RADAR: A Web Server for RNA Data Analysis and Research. Nucleic Acids Res. 35 (Web Server issue): W300-4.
  • Alcendor RR, Gao S, Zhai P, Zablocki D, Holle E, Yu X, Tian B, Wagner T, Vatner SF, Sadoshima J. (2007). Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart. Circ. Res. 100:1512-21.
  • Qiu H, Tian B, Resuello RG, Natividad FF, Peppas A, Shen Y-T, Vatner DE, Vatner SF, Depre C. (2007). Gender-specific regulation of gene expression in the aging monkey aorta. Physiol. Genomics. 29:169-80.
  • Lu B, Yadav S, Shah PG, Liu T, Tian B, Pukszta S, Villaluna N, Kutejova E, Newlon CS, Herzog JH, Suzuki CK. (2007). Roles for the human ATP-dependent Lon protease in mitochondrial DNA maintenance. J. Biol. Chem. 282:17363-74.
  • Tian B, Pan Z, Lee JY (2007). Widespread mRNA polyadenylation events in introns indicate dynamic interplay between polyadenylation and splicing. Genome Res. 17:156-65. [Rated "Must Read" by Faculty of 1000]
  • Lee JY, Yeh I, Park JY, Tian B. (2007). PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes. Nucleic Acids Res. D116-20.


  • D'mello V, Lee JY, Macdonald CC, Tian B. (2006). Alternative mRNA Polyadenylation Can Potentially Affect Detection of Gene Expression by Affymetrix GeneChip((R)) Arrays. Appl. Bioinformatics 5:249-53. [Rated "Must Read" by Faculty of 1000]
  • Ago T, Yeh I, Yamamoto M, Schinke-Braun M, Brown JA, Tian B, Sadoshima J. (2006). Thioredoxin1 Upregulates Mitochondrial Proteins Related to Oxidative Phosphorylation and TCA Cycle in the Heart. Antioxid. Redox. Signal. 8:1635-50.
  • Cheng Y, Miura RM, Tian B. (2006). Prediction of mRNA polyadenylation sites by support vector machine. Bioinformatics 22:2320-5.
  • Usui S, Yeh I, Tian B, Sadoshima J. (2006). Global changes in gene expression during cardiac hypertrophy: A new direction of cardiac signaling research. J. Mol. Cell. Cardiol. 41:219-22.
  • Lasfar A, Lewis-Antes A, Smirnov SV, Anantha S, Abushahba W, Tian B, Reuhl K, Dickensheets H, Sheikh F, Donnelly RP, Raveche E, Kotenko SV. (2006). Characterization of the Mouse IFN-lambda Ligand-Receptor System: IFN-lambdas Exhibit Antitumor Activity against B16 Melanoma. Cancer Res. 66:4468-77.
  • Pan Z, Zhang H, Hague LK, Lee JY, Lutz CS, and Tian B. (2006). An intronic polyadenylation site in human and mouse CstF-77 genes suggests an evolutionarily conserved regulatory mechanism. Gene 366:325-334.


  • Tian B#, Mukhopadhyay R, Mathews MB#. (2005). Polymorphic CUG repeats in human mRNAs and their effects on gene expression. RNA Biol. 2:149-156.
  • Zhang H, Lee JY, Tian B. (2005). Biased alternative polyadenylation in human tissues. Genome Biol. 6:R100.
  • Hu J, Lutz CS, Wilusz J, Tian B. (2005). Bioinformatic identification of candidate cis-regulatory elements involved in human mRNA polyadenylation. RNA 11:1485-1493.
  • Duttagupta1 R, Tian B, Wilusz CJ, Khounh DT, Soteropoulos P, Ouyang M, Dougherty JP, Peltz SW. (2005). Global Analysis of Pub1p targets reveals a coordinate control of gene expression through modulation of binding and stability. Mol Cell Biol. 25:5499-5513.
  • Ondrovicova G, Liu T, Singh K, Tian B, Li H, Gakh O, Perecko D, Janata J, Granoti Z, Orlyi J, Kutejova E, Suzuki CK. (2005). Cleavage site selection within a folded substrate by the ATP-dependent LON protease. J Biol Chem. 280:25103-25110.
  • Hall-Pogar T, Zhang H, Tian B, Lutz CS. (2005). Alternative polyadenylation of COX-2: a mechanism for gene regulation. Nucleic Acids Res. 33:2565-2579.
  • Liu J, Wang TL, Hu J, Tian B. (2005). A method for aligning RNA secondary structures and its application to RNA motif detection. BMC Bioinformatics 6:89.
  • Hoque M, Tian B, Mathews MB, Pe'ery T. (2005). Granulin and granulin repeats interact with the Tat:P-TEFb complexand inhibit tat transactivation. J Biol Chem. 280:13648-13657.
  • Netterwald J, Yang S, Wang W, Ghanny S, Cody M, Soteropoulos P, Tian B, Dunn W, Liu F, Zhu H. (2005). Two VRS Elements in the Human Cytomegalovirus Major Immediate-Early Promoter/Enhancer Are Important for Viral Replication. J Virol. 79:5035-5046.
  • Tian B, Hu J, Zhang H, Lutz CS. (2005). A large-scale analysis of mRNA polyadenylation of human and mouse genes. Nucleic Acids Res. 33:201-212. [Rated "Must Read" by Faculty of 1000]
  • Zhang H, Hu J, Recce M, Tian B. (2005). PolyA_DB: a database for mammalian mRNA polyadenylation. Nucleic Acids Res. D116-20.


  • Tian B, Bevilacqua PC, Diegelman-Parente A, Mathews MB. (2004). The double-stranded RNA-binding motif: Interference and much more. Nat Rev Mol Cell Biol. 5:1013-1023.
  • Toruner GA, Ulger C, Alkan M, Galante AT, Rinaggio J, Wilk R, Tian B, Soteropoulos P, Hameed MR, Schwalb MN, Dermody JJ. (2004). Association between gene expression profile and tumor invasion in oral squamous cell carcinoma. Cancer Genet Cytogenet. 154:27-35.
  • Lo JF, Hayashi M, Kim SW, Tian B, Huang JF, Fearns C, Takayama S, Zapata JM, Yang Y, Lee JD. (2004). Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor l(2)tid, is critical for early embryonic development and cell survival. Mol Cell Biol. 24:2226-2236.
  • Dai H, Tian B, Zhao D, Leung A, Smith S, Wan J, Yao X. (2004). Dynamic integration of gene annotation and its application to microarray analysis. J Bioinform Comput Biol. 1:627-645.

Bin Tian's earlier papers

  • Tian B, Mathews MB. (2003). Phylogenetics and functions of the double-stranded RNA-binding motif: a genomic survey. Prog. Nucleic Acid Res Mol Biol. 74:123-158.
  • Bonaventure P, Guo H, Tian B, Liu X, Bittner A, Roland B, Salunga R, Ma XJ, Kamme F, Meurers B, Bakker M, Jurzak M, Leysen JE, Erlander MG. (2002). Nuclei and subnuclei gene expression profiling in mammalian brain. Brain Res. 943:38-47.
  • Zhang F, Romano PR, Nagamura-Inoue T, Tian B, Dever TE, Mathews MB, Ozato K, Hinnebusch AG. (2001). Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop. J Biol Chem. 276:24946-24958.
  • Tian B, Mathews MB. (2001). Functional characterization of and cooperation between the double-stranded RNA-binding motifs of the protein kinase PKR. J Biol Chem. 276:9936-9944.
  • Taylor DR, Tian B, Romano PR, Hinnebusch AG, Lai MMC, Mathews MB. (2001). Hepatitis C virus envelope protein E2 does not inhibit PKR by simple competition with autophosphorylation sites in the RNA-binding domain. J Virol. 75:1265-1273.
  • Tian B, White RJ, Xia T, Welle S, Turner DH, Mathews MB, Thornton CA. (2000). Expanded CUG repeat RNAs form hairpins that activate the double-stranded RNA-dependent protein kinase PKR. RNA 6:79-87.

      *Equal Contribution; #Co-corresponding Author
This page was last updated on 6/28/2019
Tian Lab @ Rutgers University - New Jersey Medical School, Cancer Institute of New Jersey, Brain Health Institute