Release 3.2 (Aug 2018)


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Description:

PolyA_DB version 3.2 catalogs polyA sites (PASs) in genomes using deep sequencing data.Gene annotations are mainly based on NCBI Gene and RefSeq databases, and supplemented by the Ensembl database. Strand-specific RNA-seq data are used to extend the 3' end of genes. PASs are identified using data from the 3' end region extraction and sequencing (3'READS) method. Syntenic regions across human, mouse and rat are used to annotate conserved PASs in mammals. The current version is constructed based on ~1.2 billion 3' end sequencing reads from over 360 human, mouse and rat samples.

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References:

1. Wang R, Zheng D, Yehia G, & Tian B. (2018). A compendium of conserved cleavage and polyadenylation events in mammals. Genome Research 28(10):1427-1441.
2. Wang R, Nambiar R, Zheng D, & Tian B (2017). PolyA_DB 3 catalogs cleavage and polyadenylation sites identified by deep sequencing in multiple genomes. Nucleic Acids Research 46(D1):D315-D319.
3. Zheng D, Liu X, Tian B. (2016). 3'READS+, a sensitive and accurate method for 3' end sequencing of polyadenylated RNA. RNA.22:1631-9.
4. Hoque M*, Ji Z*, Zheng D, Luo W, Li W, You B, Park JY, Yehia G, Tian B. (2013). Analysis of alternative cleavage and polyadenylation by 3' region extraction and deep sequencing. Nature Methods 10:133-9.



Please contact Ruijia Wang/Bin Tian for questions/comments/suggestions.